What is Endocannabinoid Deficiency?

First proposed by Dr. Ethan Russo in 2001, the clinical endocannabinoid deficiency (CECD) theory implies that because of various factors, the body results in an endocannabinoid system deficiency.

It’s a theory based on neurotransmitter deficiencies that can cause even more underlying problems. In a published study from 2004, Dr. Russo explores the concept of CECD and details how:

“Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency…”

This idea suggests that through a lack of proper endocannabinoid production, or an endocannabinoid deficiency, further issues may ensue. Because the ECS can be a critical part of numerous bodily functions, including sleep, mood, clarity, and much more, endocannabinoid deficiency can cause problems that result in lingering issues.

His endocannabinoid deficiency syndrome research shows that any alterations that affect varying levels of endocannabinoids – either through the destruction and failure in production or the weakening and strengthening of cannabinoid receptors – can influence its regulatory capabilities for several functions. Clinical Endocannabinoid System (ECS) Deficiency Syndrome may be a root cause of some diseases.


What Causes Endocannabinoid Deficiency?

1. Not enough cannabinoid receptors

There simply aren’t many connectors for the endocannabinoids to attach themselves. And without a connector, the signal cannot be transmitted to its designated area.

2. An overabundance of metabolic enzymes

Meaning your body is producing too many FAAH and MAGL enzymes that break down endocannabinoid compounds or they do so too soon before the endocannabinoid can bind to a receptor.

3. Synthesising insufficient endocannabinoids

Your body isn’t correctly making AEA and 2-AG cannabinoid compounds; these deformed or incomplete molecules possibly can’t make it to the receptors or can’t attach and transmit successfully if they do arrive.

4. Not enough action between endocannabinoids and cannabinoid receptors

There isn’t adequate communication happening with the compounds and the connectors; this effect could be caused by anything from improper attachment to weak signalling.

It is believed that by supplementing the body with naturally occurring cannabinoids from plants, we can correct this deficiency, relieve symptoms, and restore health.